What is Sileo® 0.1mg/ml Oromucosal Gel for Dogs?

Sileo® 0.1mg/ml Oromucosal Gel for Dogs is used to alleviate acute fear and anxiety associated with loud noises suffered by dogs such as thunder, or fireworks around Bonfire Night or other celebrations.

The medicine should be administered to your dog directly on to the lining of the inside of the mouth between the cheek and gum (oral mucosa) at a recommended dose of 125 micrograms/m2. The Sileo oral syringe delivers it in 0.25 ml increments. 

Each of these increments is displayed as a single dot on the plunger mechanism. The dosing table indicates the number of dots to be given which corresponds to the dog’s weight. If the dog’s dosage is over 6 dots (or 1.5ml), half of the gel should be administered to one side of the mouth, the other half directly on to the other side. 

For dogs weighing 2kg to 5.5kg, the dosage is 1 dot

For dogs weighing 5.6kg to 12kg, the dosage is 2 dots

For dogs weighing 12.1kg to 20kg, the dosage is 3 dots

For dogs weighing 20.1kg to 29kg, the dosage is 4 dots

For dogs weighing 29.1kg to 39kg, the dosage is 5 dots

For dogs weighing 39.1kg to 50kg, the dosage is 6 dots

For dogs weighing 50.1kg to 62.5kg, the dosage is 7 dots

For dogs weighing 62.6kg to 75.5kg, the dosage is 8 dots

For dogs weighing 75.6kg to 89kg, the dosage is 9 dots

For dogs weighing 89.1kg to 100kg, the dosage is 10 dots

It is recommended that the initial dose is given as soon as your dog shows any signs of stress or anxiety, or when the owner hears a possible stimulus themselves, such as the noise of thunder or fireworks which may prompt fear or anxiety in their pet. 

Typical signs of fear and anxiety are sporadic or constant trembling, panting, pacing (a change of place frequently or dashing around or being restless) seeking people (clinging, following, hiding behind or pawing), hiding under furniture or in dark rooms, trying to escape, freezing (or an absence of movement), a refusal to eat treats or any food, sudden urination or inappropriate defecation or sometimes salivation. 

If the event which prompts fear carries on and the dog shows signs of fear and anxiety again, re-dosing can be done after two hours. The medicine can be dosed up to five times. 

How does Sileo® 0.1mg/ml Oromucosal Gel for Dogs work?

The active ingredient is dexmedetomidine which has the effect of binding to alpha-2 adrenoceptors in the locus coeruleus. This inhibits the release of stress hormone and neurotransmitter norepinephrine, which can have the result of limiting anxiety and any associated behaviour.

How to use Sileo® 0.1mg/ml Oromucosal Gel for Dogs

It is important that as soon as you receive and open the medication, you read and understand the instructions, especially on the recommended dose. The tablets are for oral use only with food and should not be administered in any other manner. Contact your vet to get full and detailed instructions on dosage.  

How to order Sileo® 0.1mg/ml Oromucosal Gel for Dogs

Sileo® 0.1mg/ml Oromucosal Gel for Dogs is a POM-V medication. You will need a valid written prescription from your veterinary surgeon to order this from us. Please carefully select the product and the correct strength and amount. Add it to the basket. You will be asked to upload a valid prescription (alternatively you can email it to us) and then complete checkout. Once our veterinary team reviews and validates your prescription, your order will be dispatched from the dispensary to you by your chosen delivery method.